Tuesday, June 29, 2010

A Neuroscientist Uncovers A Dark Secret

Fallon's brain scanThe criminal brain has always held a fascination for James Fallon. For nearly 20 years, the neuroscientist at the University of California-Irvine has studied the brains of psychopaths. He studies the biological basis for behavior, and one of his specialties is to try to figure out how a killer's brain differs from yours and mine.

About four years ago, Fallon made a startling discovery. It happened during a conversation with his then 88-year-old mother, Jenny, at a family barbecue.

"I said, 'Jim, why don't you find out about your father's relatives?' " Jenny Fallon recalls. "I think there were some cuckoos back there."

Fallon investigated.

"There's a whole lineage of very violent people — killers," he says.

One of his direct great-grandfathers, Thomas Cornell, was hanged in 1667 for murdering his mother. That line of Cornells produced seven other alleged murderers, including Lizzy Borden. "Cousin Lizzy," as Fallon wryly calls her, was accused (and controversially acquitted) of killing her father and stepmother with an ax in Fall River, Mass., in 1882.

A little spooked by his ancestry, Fallon set out to see whether anyone in his family possesses the brain of a serial killer. Because he has studied the brains of dozens of psychopaths, he knew precisely what to look for. To demonstrate, he opened his laptop and called up an image of a brain on his computer screen.

"Here is a brain that's not normal," he says. There are patches of yellow and red. Then he points to another section of the brain, in the front part of the brain, just behind the eyes.

"Look at that — there's almost nothing here," Fallon says.

This is the orbital cortex, the area that Fallon and other scientists believe is involved with ethical behavior, moral decision-making and impulse control.

"People with low activity [in the orbital cortex] are either free-wheeling types or sociopaths," he says.

He's clearly oversimplifying, but Fallon says the orbital cortex puts a brake on another part of the brain called the amygdala, which is involved with aggression and appetites. But in some people, there's an imbalance — the orbital cortex isn't doing its job — perhaps because the person had a brain injury or was born that way.

"What's left? What takes over?" he asks. "The area of the brain that drives your id-type behaviors, which is rage, violence, eating, sex, drinking."

Fallon says nobody in his family has real problems with those behaviors. But he wanted to be sure. Conveniently, he had everything he needed: Previously, he had persuaded 10 of his close relatives to submit to a PET brain scan and give a blood sample as part of a project to see whether his family had a risk for developing Alzheimer's disease.

After learning his violent family history, he examined the images and compared them with the brains of psychopaths. His wife's scan was normal. His mother: normal. His siblings: normal. His children: normal.

"And I took a look at my own PET scan and saw something disturbing that I did not talk about," he says.

What he didn't want to reveal was that his orbital cortex looks inactive.

"If you look at the PET scan, I look just like one of those killers."

Fallon cautions that this is a young field. Scientists are just beginning to study this area of the brain — much less the brains of criminals. Still, he says the evidence is accumulating that some people's brains predispose them toward violence and that psychopathic tendencies may be passed down from one generation to another.

And that brings us to the next part of Jim Fallon's family experiment. Along with brain scans, Fallon also tested each family member's DNA for genes that are associated with violence. He looked at 12 genes related to aggression and violence and zeroed in on the MAO-A gene (monoamine oxidase A). This gene, which has been the target of considerable research, is also known as the "warrior gene" because it regulates serotonin in the brain. Serotonin affects your mood — think Prozac — and many scientists believe that if you have a certain version of the warrior gene, your brain won't respond to the calming effects of serotonin.

Fallon calls up another slide on his computer. It has a list of family members' names, and next to them, the results of the genotyping. Everyone in his family has the low-aggression variant of the MAO-A gene, except for one person.

"You see that? I'm 100 percent. I have the pattern, the risky pattern," he says, then pauses. "In a sense, I'm a born killer."

Fallon's being tongue-in-cheek — sort of. He doesn't believe his fate or anyone else's is entirely determined by genes. They merely tip you in one direction or another.

And yet: "When I put the two together, it was frankly a little disturbing," Fallon says with a laugh. "You start to look at yourself and you say, 'I may be a sociopath.' I don't think I am, but this looks exactly like [the brains of] the psychopaths, the sociopaths, that I've seen before."

I asked his wife, Diane, what she thought of the result.

Fallon and his mother, Jenny Fallon"I wasn't too concerned," she says, laughing. "I mean, I've known him since I was 12."

Diane probably does not need to worry, according to scientists who study this area. They believe that brain patterns and genetic makeup are not enough to make anyone a psychopath. You need a third ingredient: abuse or violence in one's childhood.

"And fortunately, he wasn't abused as a young person," Diane says, "so I've lived to be a ripe old age so far." ...

via A Neuroscientist Uncovers A Dark Secret : NPR.

3 comments:

Ann said...

Interesting article, but psychopaths do differ among each other. They're not all raging, violent, eating, having sex and drinking all the time. Take for instance former President Bush. .... Oh, ... on second thought: He did ride his bicycle a lot. Maybe that took care of his waistline.

Xeno said...

Not that a scan of a particular type means you are a psychopath, but I'd really love to see a scan of W's brain... Cheney's too, just out of curiosity.

Sam said...

Actually, Xeno, I wish everyone walked around with a little scan floating over their heads. Sure would take some of the guess work out of things, huh? "Hmm. So this guy has no conscience. Okay, I am not buying a car from him."

Of course, I realize the scan is not the whole picture, but it might make a great starting point.